| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1361905 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
A series of 2,4-diaminopyrimidines was investigated and compounds were found to have in vivo efficacy against Trypanosoma brucei in an acute mouse model. However, in vitro permeability data suggested the 2,4-diaminopyrimidenes would have poor permeability through the blood brain barrier. Consequently a series of 4-desamino analogs were synthesized and found to have improved in vitro permeability.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Joe B. Perales, Jennifer Freeman, Cyrus J. Bacchi, Tana Bowling, Robert Don, Eric Gaukel, Luke Mercer, Joseph A. Moore III, Bakela Nare, Tien M. Nguyen, Robert A. Noe, Ryan Randolph, Cindy Rewerts, Stephen A. Wring, Nigel Yarlett, Robert T. Jacobs,