| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1361918 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
Active site modeling of dimerization interface in combination with site-directed mutagenesis indicates that the electron in the PrnD Rieske oxygenase can be transferred by either of two pathways, one involving Asp183′ and the other involving Asn180′. In addition, the overexpression of the isc operon involved in the assembly of iron–sulfur clusters increased the catalytic activity of PrnD in Escherichia coli by a factor of at least 4.
Graphical abstractThe electron in the PrnD Rieske oxygenase can be transferred by either of two pathways, one involving Asp183′ and the other involving Asn180′.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Manish Kumar Tiwari, Jung-Kul Lee, Hee-Jung Moon, Huimin Zhao,