| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1361926 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
A series of six-membered heterocycle carboxamides were synthesized and evaluated as cholecystokinin 1 receptor (CCK1R) agonists. A pyrimidine core proved to be the best heterocycle, and SAR studies resulted in the discovery of analog 5, a potent and structurally diverse CCK1R agonist.
Graphical abstractA series of six-membered heterocycle carboxamides were synthesized and evaluated as cholecystokinin 1 receptor (CCK1R) agonists. A pyrimidine core proved to be the best heterocycle, and SAR studies resulted in the discovery of analog 5, a potent and structurally diverse CCK1R agonist.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Liping Wang, James A. Hubert, Susan J. Lee, Jie Pan, Su Qian, Marc L. Reitman, Alison M. Strack, Drew T. Weingarth, Douglas J. MacNeil, Ann E. Weber, Scott D. Edmondson,