| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1361928 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
In order to study the SAR of 5(6)-dihydro-OSW-1, eight 15(α)β-O-glycosyl analogs (26–33) carrying three kinds of disaccharides including [β-d-Xylp-(1–3)-α-l-Arap], [β-d-Xylp-(1–4)-α-l-Arap] and [α-l-Rhap-(1–2)-(α)β-d-Glcp] were designed and synthesized. Their in vitro antitumor activities were tested by the standard MTT assay which disclosed that compound 33 (IC50 = 0.28–0.52 μM) showed potential antitumor activities.
Graphical abstractEight 15(α)β-O-glycosyl 5(6)-dihydro-OSW-1 analogs bearing three kinds of disaccharide side chains were synthesized and evaluated for their antitumor activities.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yuyao Guan, Dan Zheng, Liang Zhou, Haixing Wang, Zheng Yan, Nan Wang, Hong Chang, Pingping She, Pingsheng Lei,