| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1361937 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
Synthesis and biological evaluation of a series of 6-aminopyrazolyl-pyridine-3-carbonitriles as JAK2 kinase inhibitors was reported. Biochemical screening, followed by profile optimization, resulted in JAK2 inhibitors exhibiting good kinase selectivity, pharmacokinetic properties, physical properties and pharmacodynamic effects.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tao Wang, Stephanos Ioannidis, Lynsie Almeida, Michael H. Block, Audrey M. Davies, Michelle L. Lamb, David A. Scott, Mei Su, Hai-Jun Zhang, Marat Alimzhanov, Geraldine Bebernitz, Kirsten Bell, Michael Zinda,