| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1361949 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
The manuscript pertains to the synthesis and in vitro cytotoxic evaluation of a series of N-alkylbromo and N-alkylphthalimido-isatins against four different human cancer cell lines namely Colon: HCT-15; Liver: Hep-2; Lung: A-549 and Leukemia: THP-1 at 10 and 100 μM concentrations. The active compounds based on preliminary studies were evaluated for their IC50 value against six cell lines viz. Colo-205, HCT-15 (Colon), THP-1 (Leukemia), A-549 (Lung), PC-3 (Prostate) and HeLa (Cervix). The active analogue IS-4 exhibited IC50 values of 4.57, 10.90, 11.75, 12.40 and 54.20 μM against HeLa, PC-3, HCT-15, THP-1 and Colo-205, respectively.
Graphical abstractThe manuscript pertains to the synthesis and in vitro cytotoxic evaluation of a series of N-alkylbromo and N-alkylphthalimido-isatins against four different human cancer cell lines. The active analogue IS-4 exhibited IC50 values of 4.57, 10.90, 11.75, 12.40 and 54.20 μM against HeLa, PC-3, HCT-15, THP-1 and Colo-205, respectively.Figure optionsDownload full-size imageDownload as PowerPoint slide
