| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1361952 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
Antimicrobial compounds with broad-spectrum activity and minimal potential for antibiotic resistance are urgently needed. Toward this end, we prepared and investigated a novel series of N-chloroheterocycles. Of the compounds examined, the N-chloroamine series were found superior over N-chloroamide series in regards to exhibiting high antimicrobial activity, low cytotoxicity, and long-term aqueous stability.
Graphical abstractA novel series of N-chloroheterocycles has been prepared and the biological properties are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Charles Francavilla, Eric D. Turtle, Bum Kim, Donogh J.R. O’Mahony, Timothy P. Shiau, Eddy Low, Nichole J. Alvarez, Chris E. Celeri, Louisa D’Lima, Lisa C. Friedman, Francis S. Ruado, Ping Xu, Meghan E. Zuck, Mark B. Anderson, Ramin (Ron) Najafi,