Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1361960 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
We herein report the synthesis, biological activity and structure activity relationship of derivatives of benzylstyrylsulfone, benzylstyrylsulfine and benzylsulfonyl-N-phenylacetamide. A lead compound 7 represents a new class of mitotic inhibitors that demonstrates potent anti-proliferative activity and selectively induces cancer cell apoptosis while sparing non-transformed lung fibroblast.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Osama Chahrour, Ashraf Abdalla, Frankie Lam, Carol Midgley, Shudong Wang,