| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1361977 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
We first report that the formation of pharmaceutical co-crystal can be synchronously screened and confirmed by a simultaneous DSC-FTIR microspectroscopic system, in which this combined unique system giving spectroscopic and thermodynamic information could provide a easy and direct way for one step screening and qualitative detection of the co-crystal formation in real time.
Graphical abstractThermal-dependent three-dimensional FTIR spectral plot of the physical mixture of IMC/SAC and its temperature-dependent changes in peak intensity of the specified IR bands.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tieh-kang Wu, Shan-Yang Lin, Hong-Liang Lin, Yu-Ting Huang,