| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1361978 | Bioorganic & Medicinal Chemistry Letters | 2011 | 7 Pages |
Abstract
Continued examination of substituted 6-arylquinazolin-4-amines as Clk4 inhibitors resulted in selective inhibitors of Clk1, Clk4, Dyrk1A and Dyrk1B. Several of the most potent inhibitors were validated as being highly selective within a comprehensive kinome scan.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Andrew S. Rosenthal, Cordelle Tanega, Min Shen, Bryan T. Mott, James M. Bougie, Dac-Trung Nguyen, Tom Misteli, Douglas S. Auld, David J. Maloney, Craig J. Thomas,