Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase

The synthesis and inhibitory potencies of a novel series of β-amino alcohols, based on the hit-compound 3-[3′-(4″-cyclopent-2‴-en-1‴-ylphenoxy)-2′-hydroxypropyl]-5,5 dimethylimidazolidine-2,4-dione as specific inhibitors of mycobacterial N-acetyltransferase (NAT) enzymes are reported. Effects of synthesised compounds on growth of Mycobacterium tuberculosis have been determined.

Graphical abstractThe synthesis and in vitro characterisation of a novel series of β-amino alcohol compounds based upon the hit compound identified from a screening program 3-[3′-(4″-cyclopent-2‴-en-1‴-ylphenoxy)-2′-hydroxypropyl]-5,5-dimethylimidazolidine-2,4-dione against prokaryotic arylamine N-acetyltransferase enzymes are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide