| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1362199 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
Optimization of compounds 5 and 6 led to the discovery of VEGF inhibitor 10g which reduced CYP inhibition. It was highly active in vitro (VEGF induced HUVEC proliferation assay) and showed efficacies in three disease models in vivo (cancer, RA, and AMD).
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Related Topics
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Chemistry
Organic Chemistry
Authors
Hisashi Tajima, Takahiro Honda, Kenji Kawashima, Yoshimasa Sasabuchi, Minoru Yamamoto, Masakazu Ban, Kazuyoshi Okamoto, Kenji Inoue, Takaaki Inaba, Yuriko Takeno, Takashi Tsuboi, Asaka Tonouchi, Hiroyuki Aono,