Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1362208 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
We synthesized various substituted 8-styryl-2′-deoxyguanosine and 8-styryl-2′-deoxyadenosine derivatives. Among them only acetyl substituted 8-styryl-2′-deoxyguanosine analog 5b showed a remarkable solvatochromicity (Δλmaxem=91nm),that is, strong fluorescence at 477 nm in 1,4-dioxane, but in methanol the fluorescence was red shifted to 558 nm with very low intensity. Such environmentally sensitive solvatochromic fluorescent guanosine analogs may be useful as a sensor for investigating interactions of DNA with DNA binding proteins.
Graphical abstractChemical structures of aromatic fluorophore substituted purine nucleosides.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Katsuhiko Matsumoto, Naoya Takahashi, Azusa Suzuki, Takashi Morii, Yoshio Saito, Isao Saito,