| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1362526 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
The synthesis of a series of novel macrocyclic compounds designed to target blood coagulation Factor XIa is described. The compounds were evaluated for their inhibition of a small set of serine proteases. Several compounds displayed modest activity and good selectivity for Factor XIa. Within the series, a promising lead structure for developing novel macrocyclic inhibitors of thrombin was identified.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Stephen Hanessian, Andreas Larsson, Tomas Fex, Wolfgang Knecht, Niklas Blomberg,