Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1362542 | Bioorganic & Medicinal Chemistry Letters | 2010 | 6 Pages |
Abstract
A series of novel compound libraries inhibiting interleukin-2 inducible T cell kinase (ITK) were designed, synthesized and evaluated. In the first design cycle two library scaffolds were identified showing low micromolar inhibition of ITK. Further iterative design cycles including crystal structure information of ITK and structurally related kinases led to the identification of indolylindazole and indolylpyrazolopyridine compounds with low nanomolar ITK inhibition.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Matthias Herdemann, Isabelle Heit, Frank-Uwe Bosch, Gianluca Quintini, Claudia Scheipers, Alexander Weber,