| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1362544 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
A new class of indazole-derived bradykinin B1 antagonists and their structure–activity relationships (SAR) is reported. A number of compounds were found to have low-nanomolar affinity for the human B1 receptor and possess acceptable P-gp and pharmacokinetics properties.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Vera Bodmer-Narkevitch, Neville J. Anthony, Victoria Cofre, Samson M. Jolly, Kathy L. Murphy, Richard W. Ransom, Duane R. Reiss, Cuyue Tang, Thomayant Prueksaritanont, Douglas J. Pettibone, Mark G. Bock, Scott D. Kuduk,