| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1362546 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
A new series of 4-aryl-1-(indazol-5-yl)pyridin-2(1H)ones possessing MCH-1 receptor antagonism is presented. Suzuki coupling of boronic acids with key triflate 6 allowed rapid generation of a range of analogs. The SAR of the MCH-1 receptor was explored with a variety of aryl and heterocyclic moieties. Selected compounds were studied in a five-day diet induced obese mouse model to evaluate their potential use as weight loss agents.
Graphical abstractThe synthesis and SAR of 4-aryl-1-(indazol-5-yl)pyridin-2(1H)ones as MCH-1 antagonists are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mark Hadden, Dustin M. Deering, Alan J. Henderson, Matthew D. Surman, Michele Luche, Yuri Khmelnitsky, Steven Vickers, Jean Viggers, Sharon Cheetham, Peter R. Guzzo,