| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1362559 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
5-Benzyloxytryptamine 19 was found to act as an antagonist of the TRPM8 ion-channel. For example, 19 had an IC50 of 0.34 μM when menthol was used as the stimulating agonist. Related commercially-available tryptamine derivatives showed diminished, or no antagonist activity at TRPM8. The structural similarity of 5-benzyloxytryptamine to other literature TRPM8 antagonists was noted.
Graphical abstract5-Benzyloxytryptamine 19 was found to be an antagonist of TRPM8. Related tryptamine derivatives showed diminished, or no activity at TRPM8.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jeff DeFalco, Daniel Steiger, Michelle Dourado, Daniel Emerling, Matthew A.J. Duncton,