| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1362572 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
Utilization of a tetrahydro-pyrimdoazepine core as a bioisosteric replacement for a piperazine-urea resulted in the discovery a novel series of potent antagonists of TRPV1. The tetrahydro-pyrimdoazepines have been identified as having good in vitro and in vivo potency and acceptable physical properties.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists](/preview/png/1362572.png "First Page Preview: Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists")
Authors
Natalie A. Hawryluk, Jeffrey E. Merit, Alec D. Lebsack, Bryan J. Branstetter, Michael D. Hack, Nadia Swanson, Hong Ao, Michael P. Maher, Anindya Bhattacharya, Qi Wang, Jamie M. Freedman, Brian P. Scott, Alan D. Wickenden, Sandra R. Chaplan,