| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1362742 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Hydroxychalcones (D-501 and D-601) were studied for their radiosensitization of a colon adenocarcinoma cell line (HT-29) and a pancreatic cancer cell line (Panc 1). These chalcones produced robust radiosensitization. Compound D-601 produced radiosensitization through its metabolite as the effect was partially reduced in the presence of α-naphthoflavone (ANF), a specific inhibitor of CYP1A2.
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Authors
Rory Pruitt, Nidhish Sasi, Michael L. Freeman, Konjeti R. Sekhar,