| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1362748 | Bioorganic & Medicinal Chemistry Letters | 2010 | 6 Pages |
Abstract
We report on the discovery of 3-alkylthio-1,2,4-triazine dimers that are potently toxic to Plasmodium falciparum, with single digit nanomolar activity, and up to several thousand-fold lower toxicity to mammalian cells. They are equipotent against chloroquine-resistant strains of P. falciparum.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kung Ban, Sandra Duffy, Yelena Khakham, Vicky M. Avery, Andrew Hughes, Oliver Montagnat, Kasiram Katneni, Eileen Ryan, Jonathan B. Baell,