Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1362750 | Bioorganic & Medicinal Chemistry Letters | 2010 | 6 Pages |
Abstract
The structure–activity relationship of the prime region of hydroxyethylamine BACE inhibitors is described. Variation in the aryl linker region with 5- and 6-membered heterocycles provided compounds such as 33 with improved permeability and reduced P-gp liability compared to benzyl amine analog 1.
Graphical abstractThe structure–activity relationship of the prime region of hydroxyethylamine BACE inhibitors is described. Variation in the aryl linker region with 5- and 6-membered heterocycles provided compounds such as 33 with improved permeability and reduced P-gp liability compared to benzyl amine analog 1.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Gary D. Probst, Simeon Bowers, Jennifer M. Sealy, Brian Stupi, Darren Dressen, Barbara M. Jagodzinska, Jose Aquino, Andrea Gailunas, Anh P. Truong, Luke Tso, Ying-Zi Xu, Roy K. Hom, Varghese John, Jay S. Tung, Michael A. Pleiss, John A. Tucker,