| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1362759 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Starting from lead compound 1, we demonstrate how X-ray structural data can be used to understand SAR and expediently optimize bioavailability in a novel series of AMPA receptor modulators, furnishing 5 with improved bioavailability and robust in vivo activity.
Graphical abstractThe identification of an advanced lead compound 5 guided by structure based drug design is described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Craig Jamieson, Robert A. Campbell, Iain A. Cumming, Kevin J. Gillen, Jonathan Gillespie, Bert Kazemier, Michael Kiczun, Yvonne Lamont, Amanda J. Lyons, John K.F. Maclean, Frederic Martin, Elizabeth M. Moir, John A. Morrow, John Pantling, Zoran Rankovic,