| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1362762 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
A new series of thiazole-substituted 1,1,1,3,3,3-hexafluoro-2-propanols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Key analogs caused dose-dependent decreases in food intake and body weight in obese mice. Acute treatment with these compounds also led to a drop in elevated blood glucose in a murine model of type II diabetes.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Haifeng Tang, Yan Yan, Zhe Feng, Reynalda K. de Jesus, Lihu Yang, Dorothy A. Levorse, Karen A. Owens, Taro E. Akiyama, Raynald Bergeron, Gino A. Castriota, Thomas W. Doebber, Kenneth P. Ellsworth, Michael E. Lassman, Cai Li, Margaret S. Wu, Bei B. Zhang,