| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1362954 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
A series of 6-alkoxyisoindolin-1-ones with a magic shotgun pharmacological profile are presented as potential antipsychotics. The in vitro pharmacological profile includes D2 partial agonism (30–55%), 5-HT1A partial agonism (60–90%), and 5-HT2A antagonism. Selected compounds in this series displayed good in vivo activity and potency.
Graphical abstractA series of 6-alkoxyisoindolin-1-ones are presented as potential antipsychotics. The in vitro pharmacological profile includes D2 partial agonism (30–55%), 5-HT1A partial agonism (60–90%), and 5-HT2A antagonism. Selected compounds in this series displayed good in vivo activity and potency.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
David A. Favor, James J. Powers, Andrew D. White, Lawrence W. Fitzgerald, Vincent Groppi, Kevin A. Serpa,