| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1362966 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Optimization of a screening hit from uHTS led to the discovery of TGR5 agonist 32, which was shown to have activity in a rodent model for diabetes.
Graphical abstractOptimization of a screening hit from uHTS led to the discovery of TGR5 agonist 32, which was shown to have activity in a rodent model for diabetes.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mark R. Herbert, Dana L. Siegel, Lena Staszewski, Charmagne Cayanan, Urmi Banerjee, Sangeeta Dhamija, Jennifer Anderson, Amy Fan, Li Wang, Peter Rix, Andrew K. Shiau, Tadimeti S. Rao, Stewart A. Noble, Richard A. Heyman, Eric Bischoff, Mausumee Guha,