| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1362970 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
A series of pyrimidine derivatives as acid pump antagonists (APAs) was synthesized and the inhibitory activities against H+/K+ ATPase isolated from hog gastric mucosa were determined. After elaborating on substituents at C2 and C4 position of the pyrimidine scaffold, we have observed that the compound 7h is a potent APA with H+/K+ ATPase, IC50 = 52 nM.
Graphical abstractThe synthesis of the potent acid pump antagonist 7h (IC50 = 52 nM) is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Young Ae Yoon, Chan Sun Park, Myung Hun Cha, Hyunho Choi, Jae Young Sim, Jae Gyu Kim,