Identification of 2,3,6-trisubstituted quinoxaline derivatives as a Wnt2/β-catenin pathway inhibitor in non-small-cell lung cancer cell lines

We screened 1434 small heterocyclic molecules and identified thirteen 2,3,6-trisubstituted quinoxaline derivatives that were able to inhibit the Wnt/β-catenin signal pathway and cell proliferation. In the screen, some of the hit compounds such as the ethylene group-coupled quinoxaline derivatives were shown to hold promise for use as potential small-molecule inhibitors of the Wnt/β-catenin signal pathway in non-small-cell lung cancer cell lines.

Graphical abstractThe 1434 small molecules were screened and identified 13 number of the 2,3,6-trisubstituted quinoxaline derivatives(>1 μM) that were able to inhibit the Wnt/β-catenin signal pathway and cell proliferation.Figure optionsDownload full-size imageDownload as PowerPoint slide