| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1363009 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
HIV integrase inhibitors based on a novel bicyclic pyrimidinone core is presented. Nine variations of the core scaffold are evaluated leading to optimization of the 6:6 core giving compound 48 with an EC50 of 3 nM against wild type HIV infected T-cells.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Eric D. Jones, Nick Vandegraaff, Giang Le, Neil Choi, William Issa, Katherine Macfarlane, Neeranat Thienthong, Lisa J. Winfield, Jonathan A.V. Coates, Long Lu, Xinming Li, Xiao Feng, Changjiang Yu, David I. Rhodes, John J. Deadman,