Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1363010 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
1-(Benzothiazol-2-yl)-1-(4-chlorophenyl)ethanol (1) was identified as a positive allosteric modulator (PAM) of the CaSR in a functional cell-based assay. This compound belongs to a class of compounds that is structurally distinct from other known positive allosteric modulators e.g., the phenylalkylamines cinacalcet, a modified analog (13) potently suppressed parathyroid hormone (PTH) release in rats, consistent with its profile as a PAM of CaSRs.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Magnus Gustafsson, Jacob Jensen, Sine M. Bertozzi, Erika A. Currier, Jian-Nong Ma, Ethan S. Burstein, Roger Olsson,