| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1363335 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
The stereochemistry of the tubulin inhibitors taltobulin HTI-286 (2) and HTI-042 (3) was determined by utilizing the DPFGSE 1D NOE experiment. Single crystal X-ray diffraction analysis further confirmed the absolute configuration of these two compounds, which carry the (S,S,S)-configuration necessary for biological activity.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chuansheng Niu, Douglas M. Ho, Arie Zask, Semiramis Ayral-Kaloustian,