| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1363342 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Two novel triaryl ligands 2 and 5 with potent in vitro binding affinities for the cannabinoid subtype-2 (CB2) receptor were labeled with a positron-emitting radioactive nuclide 11C. Radioligands [11C]2, [11C]5, and their analogs [11C]3 and [11C]4 were synthesized by O-[11C]methylation of their corresponding phenol precursors with [11C]CH3I. [11C]2–5 had relatively high uptakes (>1.2% injected dose/g tissue) in mouse brains.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Masayuki Fujinaga, Katsushi Kumata, Kazuhiko Yanamoto, Kazunori Kawamura, Tomoteru Yamasaki, Joji Yui, Akiko Hatori, Masanao Ogawa, Yuichiro Yoshida, Nobuki Nengaki, Jun Maeda, Ming-Rong Zhang,