| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1363367 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
Thiazol-2-yl amine was identified as an isosteric replacement for pyrazol-3-yl amine during our efforts to identify potent and selective JAK2 inhibitors. The rationale, synthesis and biological evaluation of several analogs is reported, along with the in vivo evaluation of the lead compounds.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Stephanos Ioannidis, Michelle L. Lamb, Lynsie Almeida, Huiping Guan, Bo Peng, Geraldine Bebernitz, Kirsten Bell, Marat Alimzhanov, Michael Zinda,