Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1363386 | Bioorganic & Medicinal Chemistry Letters | 2010 | 6 Pages |
Abstract
The synthesis, structure–activity relationship (SAR) studies and intramolecular hydrogen bonding pattern of 1,3,5-trisubstituted 4,5-dihydropyrazoles are described. The target compounds 6–18 represent a novel class of potent and selective CB1 receptor antagonists. Based on X-ray diffraction data, the orally active 17 is shown to elicit a different intramolecular H-bonding mode as compared to ibipinabant (3) and SLV330 (4).
Graphical abstractCompound 17 was shown to elicit an unexpected intramolecular H-bonding pattern.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jos H.M. Lange, Martina A.W. van der Neut, Arnold P. den Hartog, Henri C. Wals, Jan Hoogendoorn, Herman H. van Stuivenberg, Bernard J. van Vliet, Chris G. Kruse,