| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1363389 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
A small molecule (1835F03) that inhibits Staphylococcus aureus wall teichoic acid biosynthesis, a proposed antibiotic target, has been discovered. Rapid, parallel, solution-phase synthesis was employed to generate a focused library of analogs, providing detailed information about structure–activity relationships and leading to the identification of targocil, a potent antibiotic.
Graphical abstractThe synthesis and biological evaluation of a focused library of wall teichoic acid biosynthesis inhibitors is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kyungae Lee, Jennifer Campbell, Jonathan G. Swoboda, Gregory D. Cuny, Suzanne Walker,