| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1363393 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
The acyloxyalkyl derivatives of a model anti-HBV dinucleotide were synthesized and evaluated as orally bioavailable prodrugs. Our studies have led to the identification of the first orally bioavailable dinucleotide prodrugs for further therapeutic development against the hepatitis B virus (HBV).
Graphical abstractNovel acyloxyalkyl dinucleotide prodrugs have been developed as orally bioavailable anti-HBV agents.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
John E. Coughlin, Seetharamaiyer Padmanabhan, Guangrong Zhang, Cassandra J. Kirk, Chandrika P. Govardhan, Brent E. Korba, Kathleen O’Loughlin, Carol E. Green, Jon Mirsalis, John D. Morrey, Radhakrishnan P. Iyer,