| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1363539 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Replacement of a phenyl ring with N-linked heterocycles in a series of quinolone carboxylic acid M1 positive allosteric modulators was investigated. In particular, a pyrazole derivative exhibited improvements in potency, free fraction, and CNS exposure.
Graphical abstractReplacement of a phenyl ring with N-linked heterocycles in a series of quinolone carboxylic acid M1 positive allosteric modulators was investigated. In particular, a pyrazole derivative exhibited improvements in potency, free fraction, and CNS exposure.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Scott D. Kuduk, Christina N. Di Marco, Victoria Cofre, Daniel R. Pitts, William J. Ray, Lei Ma, Marion Wittmann, Lone Veng, Matthew A. Seager, Kenneth Koeplinger, Charles D. Thompson, George D. Hartman, Mark T. Bilodeau,