| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1363561 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Design and synthesis of pyrazolodihydropyrimidines as KV1.5 blockers led to the discovery of 7d as a potent and selective antagonist. This compound showed atrial selective prolongation of effective refractory period in rabbits and was selected for clinical development.
Graphical abstractDesign and synthesis of pyrazolodihydropyrimidines as KV1.5 blockers led to the discovery of 7d as a potent and selective antagonist. This compound showed atrial selective prolongation of effective refractory period in rabbits and was selected for clinical development.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Authors
John Lloyd, Heather J. Finlay, Wayne Vacarro, Tram Hyunh, Alexander Kover, Rao Bhandaru, Lin Yan, Karnail Atwal, Mary Lee Conder, Tonya Jenkins-West, Hong Shi, Christine Huang, Danshi Li, Huabin Sun, Paul Levesque,