| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1363564 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
The synthesis, SAR and binding affinities of cannabinoid-1 receptor (CB1R) inverse agonists based on furo[2,3-b]pyridine scaffolds are described. Food intake, mechanism specific efficacy, pharmacokinetic, and metabolic evaluation of several of these compounds indicate that they are effective orally active modulators of CB1R.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Furo[2,3-b]pyridine-based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation. Part 1](/preview/png/1363564.png "First Page Preview: Furo[2,3-b]pyridine-based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation. Part 1")
Authors
John S. Debenham, Christina B. Madsen-Duggan, Richard B. Toupence, Thomas F. Walsh, Junying Wang, Xinchun Tong, Sanjeev Kumar, Julie Lao, Tung M. Fong, Jing Chen Xiao, Cathy R.-R.C. Huang, Chun-Pyn Shen, Yue Feng, Donald J. Marsh, D. Sloan Stribling,