| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1363670 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
In this Letter, we report our strategy to design potent and metabolically stable γ-secretase inhibitors that are efficacious in reducing the cortical Aβx-40 levels in FVB mice via a single PO dose.
Graphical abstractIn this Letter, we report our strategy to design potent and metabolically stable γ-secretase inhibitors that are efficacious in reducing the cortical Aβx-40 levels in FVB mice via a single PO dose.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Anh P. Truong, Danielle L. Aubele, Gary D. Probst, Martin L. Neitzel, Chris M. Semko, Simeon Bowers, Darren Dressen, Roy K. Hom, Andrei W. Konradi, Hing L. Sham, Albert W. Garofalo, Pamela S. Keim, Jing Wu, Michael S. Dappen, Karina Wong, Erich Goldbach,