| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1363698 | Bioorganic & Medicinal Chemistry Letters | 2009 | 6 Pages |
Abstract
A novel series of carbamates was discovered as potent and selective HER-2 sheddase inhibitors. Significant enhancement in potency and selectivity was achieved through attenuating the P1 moiety, which was conventionally believed to be exposed to solvent.
Graphical abstractA novel series of carbamates was discovered as potent and selective HER-2 sheddase inhibitors. Significant enhancement in potency and selectivity was achieved through attenuating the P1 moiety.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yun-Long Li, Eric Shi, David Burns, Yanlong Li, Maryanne B. Covington, Maxwell Pan, Peggy Scherle, Steve Friedman, Brian Metcalf, Wenqing Yao,