| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1363700 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
Several novel amine substituted N-(1H-benzimidazol-2ylmethyl)-5,6,7,8-tetrahydro-8-quinolinamines were synthesized which had potent activity against HIV-1. The synthetic approaches adopted allowed for variation of the substitution pattern and resulting changes in antiviral activity are highlighted. This led to the identification of compounds with low and sub-nanomolar anti-HIV-1 activity.
Graphical abstractSynthesis of several novel and very potent substituted N-(1H-benzimidazol-2ylmethyl)-5,6,7,8-tetrahydro-8-quinolinamines are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kristjan S. Gudmundsson, Paul R. Sebahar, Leah D’Aurora Richardson, John F. Miller, Elizabeth M. Turner, John G. Catalano, Andrew Spaltenstein, Wendell Lawrence, Michael Thomson, Stephen Jenkinson,