| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1363711 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
2-Piperazinyl naphthoquinones (2) and 2-piperidinyl naphthoquinones (3) were designed and synthesized as new cytotoxic and apoptosis inducing agents by utilizing the anti-parasite drug atovaquone as lead compound. Several compounds displayed significantly improved cytotoxic activities against a panel of cancer cell lines than that of atovaquone. These compounds also induced apoptosis through activating pro-apoptotic caspases 9 and 3.
Graphical abstract2-Piperazinyl and 2-piperidinyl analogues of anti-parasite atovaquone were designed and synthesized as potent cytotoxic and apoptosis inducing agents.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jing Zhou, Lei Duan, Huaming Chen, Xiaomei Ren, Zhang Zhang, Fengtao Zhou, Jinsong Liu, Duanqing Pei, Ke Ding,