| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1363718 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A series of 2,4-diaminopyridine derivatives was synthesized and evaluated as potential candidates for neuropeptide Y (NPY) Y1 receptor positron emission tomography (PET) tracers. Derivatives bearing substitutions allowing reliable access to radiolabeling were designed, focusing on Y1 binding affinity and lipophilicity. The advanced derivatives 2n and 2o were identified as promising PET tracer candidates.
Graphical abstractThe identification of 2n and 2o as potential NPY Y1 PET tracer candidates is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Minoru Kameda, Makoto Ando, Chisato Nakama, Kensuke Kobayashi, Hiroshi Kawamoto, Sayaka Ito, Tomoki Suzuki, Takeshi Tani, Satoshi Ozaki, Shigeru Tokita, Nagaaki Sato,