| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1363727 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
4-Butyl-3-methylphthalic acid was recognized as a metallo-β-lactamase inhibitor. The structure–activity relationship study of substituted phthalic acids afforded 3-phenylphthalic acid derivatives as potent IMP-1 inhibitors. On the other hand, 3-substituted with 4-hydroxyphenyl phthalic acid derivative displayed a potent combination effect with biapenem (BIPM) against Pseudomonas aeruginosa that produce IMP-1.
Graphical abstract3-Substituted phthalic acid derivatives showed potent IMP-1 inhibitory activity, moreover these compounds have combination effect with Biapenem against Pseudomonas aeruginosa that produces IMP-1.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yukiko Hiraiwa, Akihiro Morinaka, Takayoshi Fukushima, Toshiaki Kudo,