| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1363731 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A series of diaryl ureas with an amide substitution at the 4-position was prepared and found to be potent and selective FLT3 inhibitors with good oral bioavailability and efficacy in a tumor xenograft model.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hitesh K. Patel, Robert M. Grotzfeld, Andiliy G. Lai, Shamal A. Mehta, Zdravko V. Milanov, Qi Chao, Kelly G. Sprankle, Todd A. Carter, Anne Marie Velasco, Miles A. Fabian, Joyce James, Daniel K. Treiber, David J. Lockhart, Patrick P. Zarrinkar,