| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1363739 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A series of novel 1,3-benzodiazapine based D1 antagonists was designed according to the understanding of pharmacophore models derived from SCH 23390 (1b), a potent and selective D1 antagonist. The new design features an achiral cyclic-amidine that maintains desired basicity. Solid phase synthesis was developed for SAR development of the novel dopamine antagonists.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zhaoning Zhu, Zhong-Yue Sun, Yuanzan Ye, Brian McKittrick, William Greenlee, Michael Czarniecki, Ahmad Fawzi, Hongtao Zhang, Jean E. Lachowicz,