| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1363745 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
β2-Adrenoceptor agonists with basic and acidic groups attached via an alkyl linker to the phenyl ethanolamine core were prepared and investigated in vitro and in vivo. The compounds exhibited a high potency in a functional cellular assay and a bronchoprotective effect in a guinea pig model which lasted over the complete study period of 5 h.
Graphical abstractβ2-Adrenoceptor agonists with basic and acidic groups R were prepared and investigated in vitro and in vivo.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Thierry Bouyssou, Klaus Rudolf, Christoph Hoenke, Philipp Lustenberger, Andreas Schnapp, Ingo Konetzki,