Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1363748 | Bioorganic & Medicinal Chemistry Letters | 2009 | 6 Pages |
Abstract
The synthesis and structure–activity relationship of a series of novel gp120-CD4 inhibitors are described. Pharmacokinetic studies and antiviral spectrum assessment of lead compounds led to the identification of compound 36, a potent gp120-CD4 inhibitor which exhibited antiviral potency across a spectrum of 25 clade B isolates.
Graphical abstractThe synthesis and SAR of a series of novel gp120-CD4 inhibitors are described. Pharmacokinetic studies and antiviral spectrum assessment of lead compounds led to the identification of compound 36.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Thien-Duc Tran, Fiona M. Adam, Frederick Calo, David R. Fenwick, Juin Fok-Seang, Iain Gardner, Duncan A. Hay, Manos Perros, Jaiessh Rawal, Donald S. Middleton, Tanya Parkinson, Christopher Pickford, Michelle Platts, Amy Randall, Peter T. Stephenson,