| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1363940 | Bioorganic & Medicinal Chemistry Letters | 2009 | 6 Pages |
Abstract
An effort aimed at exploring structural diversity in the N-pyrazole-N′-naphthylurea class of p38 kinase inhibitors led to the synthesis and characterization of N-phenyl-N′-naphthylureas. Examples of these compounds displayed excellent inhibition of TNF-α production in vitro, as well as efficacy in a mouse model of lipopolysaccharide induced endotoxemia. In addition, perspective is provided on the role of a sulfonamide functionality in defining inhibitor potency.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Pier F. Cirillo, Eugene R. Hickey, Neil Moss, Steffen Breitfelder, Raj Betageri, Tazmeen Fadra, Faith Gaenzler, Thomas Gilmore, Daniel R. Goldberg, Victor Kamhi, Thomas Kirrane, Rachel R. Kroe, Jeffrey Madwed, Monica Moriak, Matthew Netherton,